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b Estimated using an ANCOVA based on data irrespectively of discontinuation of trial product or initiation of rescue medication adjusted for baseline value, background medication, renal status and region

This can worsen constipation rather than relieve it

When used, signal modulation occurs at varying frequencies to achieve the required effects

Certain NSAIDs (e.g., selective COX-2 inhibitors) have been linked to an increased risk of cardiovascular events, in particular heart attack

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