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The most comprehensive review to date, published in JAAOS Global Research & Reviews , reached the same conclusion: Although preclinical studies are promising, there is a current lack of clinical trials (Rahman et al., 2026)

Vasculogenesis in tumors is mediated by recruitment of EPCs or bone marrowderived hematopoietic cells, resulting in the formation of new vessels to support tumor growth [44, 45]

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