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At the signaling pathway level, ROS down-regulate PR signaling through NF-B/MAPK signaling pathway, and then inhibit the transcription of PRL and IGFBP-1 (77, 78)
Glutathione protects these cells and the ovaries for oxidative damage, contributing to overall egg quality
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doi: 10.1016/j.bcp.2015.04.007 142
The FDA classifies semaglutide and tirzepatide as Category C medications, meaning animal reproduction studies have shown adverse effects, but no adequate human studies exist
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