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Additionally, obesity and IR both contribute to -cell dysfunction and apoptosis, mechanistically explained by glucotoxicity and increased immunogenicity (the accelerator hypothesis) or by -cell exhaustion due to increased metabolic demand (the overload hypothesis) [23]

Across premenopausal, perimenopausal, and postmenopausal women, tirzepatide produced similar reductions in body weight, waist circumference, and central adiposity

It may not be suitable for individuals with certain medical conditions, including specific thyroid issues or those advised against GLP-1 medications by a healthcare provider

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1 Researchers acknowledged the genetic effect on weight loss was relatively small but said the findings lay the foundation for precision medicine approaches to obesity treatment by providing direct evidence that variation in drug-target genes contributes to differences in how patients respond

Average plasma glucose levels before breakfast, lunch, and dinner, and the decreased amplitude of glycemic excursions were calculated