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MOTS-c is the peptide most directly tied to mitochondrial function, since it is encoded in mitochondrial DNA and signals mitochondrial stress [2][3]

It is also worth noting that while semaglutide has not been linked to an increased risk of cancer, people with type 2 diabetes have an increased risk of developing certain types of cancer, such as liver and pancreatic cancer

X.et al (2017)

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Retatrutide is not yet approved by the FDA or TGA

Despite the absence of a prolonged anorectic effect, Cagrilintide produced a sustained and significant reduction in body weight in WT mice by 3.4 g after 21 days, while no such effect was observed in KO animals