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I use them in coffee enemas

Authors: Wu G, Fang YZ, Yang S, Lupton JR, Turner ND

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Effect of Lactobacillus plantarum 299v treatment in an animal model of irritable bowel syndrome

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Studies have shown that it can reduce the expression of pro-inflammatory cytokines such as Tumour Necrosis Factor-alpha (TNF-) and Interleukin-6 (IL-6)