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For this reason, only RCTs on OMMs were considered, whereas studies on lifestyle and bariatric surgery were not included in this systematic review

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Insulin remains the preferred choice only when GLP-1 drugs are contraindicated, unaffordable, or insufficient alone, or when the patient has Type 1 diabetes

Additionally, Tesamorelin has demonstrated efficacy in improving lipid profiles and reducing liver fat content in clinical studies, further underscoring its therapeutic potential in managing HIV-associated complications

Our findings suggest that compared to insulin therapy, the higher drug acquisition, pharmacy, and outpatient costs associated with the real-world use of a GLP-1RA is offset by a reduction in healthcare-related expenses associated with emergency room visits and inpatient admissions owing to reduced risks of all-cause mortality and hospitalized hypoglycemia

Propensity score matching (1:1) was performed between the groups (n=2867 in each), using 82 clinical and demographic variables, including age, sex, race, AF subtype, cardiovascular comorbidities, and baseline medications