Example 19 preparation of Semetreuptade 59.4 g of the peptide resin obtained in example 15 was added to a 2000ml single-neck flask, and lysate 600ml of TFA was prepared in advance: and (3) TIS: EDT (electro-thermal transfer coating): PhOH: H2O 90:3:3:2:2 (vol.%), the lysate was added to the flask, the reaction was carried out at room temperature for 2.5 hours, the resin was filtered off, the resin was washed with 50ml tfa, the filtrates were combined, 6000ml of anhydrous ether was added to precipitate a white solid, the solid was centrifuged, the solid was washed with anhydrous ether, and 20.2 g of crude semaglutide peptide was dried in vacuo to a white solid, with a yield of 98.24%
This means people who drink instant coffee might face a greater risk of getting multiple myeloma than those who drink other types or none at all
J Biol Chem 257(8):42484252 Bautista AP, Mszros K, Bojta J, Spitzer JJ (1990) Superoxide anion generation in the liver during the early stage of endotoxemia in rats
Influenza A virus neuraminidase enhances meningococcal adhesion to epithelial cells through interaction with sialic acid-containing meningococcal capsules
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