To view or add a comment, sign in FDA Many thanks to Linda Frew Shostak The CDER Guidance Agenda updates FDA's planned draft guidance portfolio for 2026, it outlines FDA CDER's planned new and revised draft guidance documents expected during calendar year 2026
Phase 2 trial data Tirzepatide Phase 3 trials (SURPASS and SURMOUNT programs) demonstrated weight loss of 15 to 22.5% body weight depending on dose and study population
For researchers focused specifically on MASLD, mazdutide offers an excellent risk-benefit profile
Cagrilintide is a long-acting amylin analog that works on the satiety pathway, the signal that tells your brain you are full and keeps you full, so appetite quiets and weight loss becomes sustainable rather than a constant fight

KPVs unique mechanisms: Blocks NF-B pathway a master inflammatory switch Reduces inflammatory cytokines without immune suppression Promotes wound healing and tissue repair Modulates mast cell activation in allergic responses KPV is particularly valuable for: Inflammatory bowel conditions Skin conditions like eczema and psoriasis Allergic responses and sensitivities Chronic inflammatory pain The Real-World Results: What Im Seeing in Practice When patients combine these immune-modulating peptides with comprehensive lifestyle optimization, the results are often dramatic: Within 2-4 weeks: Reduced brain fog and fatigue Less joint pain and stiffness Fewer inflammatory flares Better stress tolerance By 8-12 weeks: Significant improvement in autoimmune markers Increased resistance to infections Better gut health and digestion Improved energy and sleep quality After 3-6 months: Sustained remission of autoimmune symptoms Normal inflammatory markers Restored immune balance Return to normal activity levels These improvements are measurable through laboratory testing we track inflammatory markers, immune cell function, and autoimmune antibodies to document progress

Adding copper peptides, whether topically or through injection, could potentially worsen copper accumulation