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Yamamoto, and H
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NNMT inhibitors show promise in suppressing obesity and increasing metabolic health
Timing fiber intake, particularly soluble fiber, around meals can help to minimize postprandial glucose spikes by slowing down the absorption of glucose during digestion, leading to a more gradual rise in blood glucose and lasting feelings of satiety following meals
Regarding fibrosis, while direct anti-fibrotic mechanisms are less established, preclinical studies indicate that GLP-1 RAs could suppress fibrogenic cell activation and reduce expression of pro-fibrotic genes encoding extracellular matrix proteins, potentially facilitating fibrosis regression in conjunction with improvements in steatosis and inflammation [29-32]
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