71 In addition, extra-mitochondrial localization of branched-chain -keto acid dehydrogenase (BCKDH), a rate-limiting enzyme in BCAAs metabolism, has been reported in type 2 diabetic rat model (OLETF)
Contrary to common belief, caffeinated beverages do generally count toward hydration goals, though moderation is advised (FDA considers up to 400mg caffeine daily generally safe for most adults)

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However, there are some BCAA negatives to consider as well and supplementation may not be right for everyone
& Kandel, R
The recommended dosage is one tablet per day, preferably taken after meals with a glass of water