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Oxidative stress, marked by an excess of ROS relative to antioxidant systems, is a key pathological mechanism in hypertension
Of the cohort studies already included above 187,190,192 , two report additional results of relevance
The strongest human data comes from a 2022 study showing MOTS-c rises in skeletal muscle after long-term physical activity and improves acute exercise performance after a single dose (Hyatt et al., 2022, Physiological Reports, PMC9270643)
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