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The presence of GLP-1 receptors in the central nervous system, particularly in the ventral tegmental area (VTA) and nucleus accumbens (NAc), suggests their involvement in reward processing and motivation
Maximum: 20 mg daily Extended release Initial: 2.55 mg once daily with first main meal Maximum: 20 mg daily Glimepiride (Amaryl) Dosage Initial: 12 mg once daily with first main meal Maximum: 8 mg daily Possible side effects include: Hypoglycemia Weight gain Meglitinides (glinides) Primary mechanism(s) of action Meglitinides stimulate insulin release by pancreatic beta cells
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Cani PD, Lecourt E, Dewulf EM, et al
Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides
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