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M., Calabr, V., Guido, S

doi:10.1074/mcp.M113.030437 Jones DP (2006) Extracellular redox state: refining the definition of oxidative stress in aging

On the other hand, SWI/SNF-proficient H2122 cells have KEAP1 mutation (A170_R204del), which leads to activation of NRF2 30

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It catalyzes the peroxidase cycle through a Cys mechanism in which GSH and protein disulfide isomerases,are alternative substrates, allowing rapid reactivity with thioredoxin (Trx) or proteins related to most other CysGPx