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GPx reduce potentially damaging reactive oxygen species (ROS), such as hydrogen peroxide and lipid hydroperoxides, to harmless products like water and alcohols by coupling their reduction with the oxidation of glutathione ( Figure 2 ) (73, 74)

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For comparison, the FDA's 2003 guidance on pharmacokinetics in patients with impaired hepatic function recommends that drugs primarily cleared by the liver undergo dedicated studies across Child-Pugh categories A, B, and C [9]

References: National Research Council (US) Committee on Diet and Health

The G6PD gene contributes to the production of glucose-6-phosphate dehydrogenase

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