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However, it can also put pressure on the lower esophageal sphincter (LES), allowing acid to flow back into the esophagus, which can cause irritation and a burning sensation in the chest (heartburn)

PT-141 , Bremelanotide , was derived directly from MT-II through C-terminal amide hydrolysis, producing a compound that retains the cyclic heptapeptide structure and MC3R/MC4R pro-sexual activity while reducing MC1R-mediated tanning