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Fifth, other studies have reported high one-year discontinuation rates (64.8% in non-T2DM and 46.5% in T2DM cohorts) and low 1-year re-initiation rates of GLP-1RA (36.3% in non-T2DM and 47.3% in T2DM cohorts), largely contributed by moderate or severe incident gastrointestinal adverse events and lower income status [107,108,109,110,111]

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N-terminal acetylation of antimicrobial peptide L163 improves its stability against protease degradation

This difference could potentially explain the greater weight loss observed with retatrutide in trials

Synthetic GLP-1 analogs like semaglutide, liraglutide, and tirzepatide are engineered to resist breakdown, providing longer-lasting effects with once-weekly or once-daily dosing