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Furthermore, the purpose of this review is to discuss the putative mechanisms by which specific bacterial metabolites, such as short chain fatty acids, trigger GLP-1 secretion through GPR41/43-dependent mechanisms
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In the pancreatic islets, activation of GLP-1R results in activation of adenylyl cyclase and generation of cAMP, activating various downstream mediators through protein kinase A
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Vomiting was not reported among any VK2735-treated subjects
Results have not been independently verified and may vary from person to person
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