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If methylation is sluggish (often for genetic reasons) or the body doesn't have enough nutrients (including vitamin B12 and folate) to turn the methylation cycle, the body can't make enough glutathione
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10.1186/1475-2859-12-56 Microb
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Berberine, a natural alkaloid and key bioactive constituent of traditional Chinese medicinal herbs, suppresses tubular pyroptosis, thereby mitigating renal inflammation and interstitial fibrosis in DKD (170)
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