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these neoplasms are characterized by a high number of point mutations, mostly consisting in the so-called UV signature (cytosine to thymidine transitions at dipyrimidine sites)
Brown, C
Lima, R
Before considering any longevity focused intervention, its important to understand your current metabolic health, inflammation, nutrient status, and biological drivers
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that emphasized the importance of reaching adequate glycemic control and body weight loss as a common goal to improve the cardiovascular safety of these individuals
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