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This accounts for the inevitable dose escalation most patients experience
However, discontinuation rates are similar for both treatments (approximately 6%), suggesting that while CagriSema causes more frequent gastrointestinal symptoms, they are generally manageable
GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, an incretin hormone released from intestinal L-cells in response to food intake
No validated human protocols exist
Kellar and Craft, 2020), even in the absence of concomitant diabetes (Schrijvers et al., 2010)
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