Allison Whitten AstraZeneca reports mixed Phase 3 results across oncology and rare disease AstraZeneca reported mixed late-stage clinical results, with its Claudin 18.2-targeting antibody-drug conjugate sonesitatug vedotin meeting its primary endpoint in patients with previously treated advanced gastric cancer, while rare disease therapy Ultomiris missed the primary endpoint in a Phase 3 trial for thrombotic microangiopathy following haematopoietic stem cell transplantation (HSCT-TMA)
PT-141 (bremelanotide) and PT-141 nasal spray formulations have specific stability requirements depending on formulation
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After first puncture, the 28-day multi-dose window starts, and refrigeration at 2-8C is consistently cited as the documented best practice in community and pharmaceutical references
Middle-aged adults (30-60) Represent the primary target population with standard dosing protocols directly applicable
Histological examination showed reduced liver necrosis and restored tissue morphology in transplanted mice