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In December 2025, the TGA updated contraception advice for tirzepatide and said reduced effectiveness of oral contraception during treatment initiation or dose escalation could not be ruled out
The Bottom Line GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound are revolutionizing weight loss treatment, but they dont work equally well for everyone
Beyond the average, the distribution of results is striking
Li N., Zhou G., Zheng Y., et al
You have thyroid/graves disease (medication may cause pigment to not retain well)
GLP-1 peptides like cagrilintide and semaglutide are extremely potent at small doses, so some researchers use as little as 0.5-1 mL for these compounds
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