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Substance-use disorders Pre-clinical and mechanistic studies A large body of pre-clinical and mechanistic literature is available regarding the putative effects of GLP-1RAs on substance misuse (Supplementary Section 5): 24 for alcohol 59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82 , 8 for opiates 63,83,84,85,86,87,88,89 , 16 for stimulants, including cocaine and amphetamines 90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105 , and 4 for nicotine 106,107,108,109
Some people may experience loose stools, urgent bowel movements, or stomach discomfort after starting treatment or increasing the dosage
What GLP-1 therapy does not do is reverse every hormonal change of menopause on its own
Upon discontinuation, some individuals may experience weight regain , particularly if dietary and lifestyle modifications are not maintained
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At Restore, we take great care to formulate our GLP-1 compound in accordance with stringent safety guidelines
