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Additional effects include uncoupling of the electron transport chain to produce heat [185, 189]
It is a frustrating "vicious cycle": a slow thyroid leads to poor protein digestion, which leads to a lack of amino acids, which further slows the thyroid
doi: 10.1016/j.biopha.2020.110439 271 Sa-nguanmooPTanajakPKerdphooSJaiwongkamTWangXLiangGet al
The presence of multiple GSTs with overlapping functions and substrate specificities might preclude the observation of phenotypic alteration in knockout mutants (Sappl et al., 2009)
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However, this advantage diminishes with combination therapy
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