Animal model studies demonstrate a biphasic response curve where low micromolar concentrations (110 M) produce maximal NF-B inhibition, while concentrations above 50 M show diminishing returns and, in some tissue types, paradoxical pro-inflammatory signaling
Recovery typically requires 6 to 12 months before return to running
It has, however, been linked to alterations in the hypothalamic-pituitary-adrenal axis
Starting at the lower end and adjusting based on individual response is the approach we follow at Trusta Clinic because no two patients heal at the same rate, and no two injuries are identical
In addition to these mechanisms, there are other non-enzymatic antioxidants within cells that can directly interact with free radicals and scavenge them, thereby mitigating harmful lipid peroxidation and preventing ferroptosis
Reaching these doses requires eight to sixteen weeks of gradual escalation for each component, with coordination to avoid escalating both simultaneously