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Although tissue-specific differences in hepcidin sensitivity, along with variations in critical thresholds, time kinetics and the compensatory capability of cellular antioxidant defense systems, may modulate iron accumulation and ferroptotic outcomes, existing evidence supports a pro-ferroptotic role of hepcidin in Kupffer cells, neurons and hepatocytes (65-67)
Bajerska, J., Jeszka, J., Czapka-Matyasik, M., and Kostrzewa-Tarnowska, A