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The cascade signaling also suffers from oxidative stress in that it affects the activation of protein kinase C (PKC) [37], a serine/threonine kinase pathway that forms part of the mitogenic protein kinase (MAPK) [42] and plays an important role in several intracellular processes such as signal transduction, response to specific hormonal, neuronal and growth factor stimuli [28, 40]

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Well, it depends

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Therefore, combinatorial therapeutic strategies designed to dismantle these adaptive mitochondrial dynamics alongside standard platinum-based therapy hold the greatest clinical promise for resensitizing resistant HGSOC tumors