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doi: 10.1016/j.ymeth.2018.03.012 45 RomeroEGmez CastellanosJRGaddaGFraaijeMWMatteviA

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The triple agonist mechanism is fully engaged

[194] Following amphetamine uptake at VMAT2, amphetamine induces the collapse of the vesicular pH gradient, which results in a dose-dependent release of dopamine molecules from synaptic vesicles into the cytosol via dopamine efflux through VMAT2

As well as being a precursor to several diseases, oxidative stress is also believed to cause inflammation and contribute to visible aging