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Dual GIP/GLP-1 receptor agonists Sometimes called dual agonists or twincretins, as they activate the GLP-1 receptor plus a second receptor, called GIP (glucose-dependent insulinotropic polypeptide)

Given that high IGF-1 levels may increase risk for certain cancers or make them more difficult to treat, its natural to wonder if you should try to lower your IGF-1 levels

In both male and female GHRKO mice, disruption of the GH/IGF-1 axis from birth results in mice that are remarkably long lived, but temporal disruption of this pathway in young adults (aGHRKO mice) improves lifespan only in females 17 , an observation which is consistent with the beneficial effects of targeting IGF-1R signaling post-development on female healthspan and aging in this study

New Phytol 157:135143 Pucciariello C, Innocenti G, Van de Velde W, Lambert A, Hopkins J, Clment M, Ponchet M, Pauly N, Goormachtig S, Holsters M, Puppo A, Frendo P (2009) (Homo)glutathione depletion modulates host gene expression during the symbiotic interaction between Medicago truncatul a and Sinorhizobium meliloti

GLP-1 stands for glucagon-like peptide-1 , a hormone made in the intestines

SCFAs including acetate, propionate, and butyrate are created by gut bacteria during the fermentation of dietary fiber and play an important role in maintaining intestinal health and lowering inflammation