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Peer review Peer review information Nature Communications thanks Rudolf Oehler, Robert Hoffman and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

By activating these receptors, GLP-1 therapy can naturally decrease appetite, helping you feel satisfied with smaller portions and supporting long-term weight loss efforts

The MHRA approved it on 11 June 2026

Vagaries of conditional gene targeting

Patients should seek urgent medical attention if they experience severe, persistent abdominal pain (which may indicate pancreatitis) or symptoms of gallbladder disease (right upper abdominal pain, fever, jaundice)

Diarrhea lasted a median of 3 days