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Phenylacetylglutamine increases the susceptibility of ventricular arrhythmias in heart failure mice by exacerbated activation of the TLR4/AKT/mTOR signaling pathway
It may also have anti-aging effects and may help to reduce the risk of certain diseases, such as diabetes and cancer
doi: 10.3389/fbioe.2025.1729166 Received 21 October 2025 Revised 01 December 2025 Accepted 17 December 2025 Published 15 January 2026 Volume 13 - 2025 Edited by Ling Wang, Dalian Medical University, China Reviewed by Nicola Alessio, University of Campania Luigi Vanvitelli, Italy Yesuf Adem Siraj, Bahir Dar University, Ethiopia Updates Copyright 2026 Hu, Li, Hu, Shan, Tang, Jiang, Yi, Chen, Jin, Wang and Wang
Designed to manage type 2 diabetes by regulating blood sugar, slowing digestion and reducing appetite, GLP-1s are now taken by millions of people across the world for weight loss, with Australian prescriptions increasing almost 10-fold since 2020 and use in the US more than quadrupling
This signalling cascade influences gene transcription, ion channel activity, and cellular metabolism
To combat dehydration, consider keeping a water bottle by your bedside or setting reminders throughout the day to ensure youre consuming adequate fluids
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