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Conversely, people who already present with high anhedonia, for instance, in the context of a depressive illness, may see their symptoms worsening when on GLP-1RAswhich could elucidate some of the studies reporting negative effects associated with these medications in mood and anxiety disorders

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MCP-1, CXCL10, and RANTES are known to be upregulated and involved in chemokine signaling in peripheral neuroinflammatory responses 16