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76 Studies have shown that within various cell types, including vascular smooth muscle cells, endothelial cells, adipocytes, hepatocytes, pancreatic islet cells, and renal tubular cells, uric acid can activate NADPH oxidase, a crucial enzyme involved in the generation of reactive oxygen species

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[65] This nutrient deficiency/disease correlation, however, has been hypothesized to reveal a risk factor for autism that could potentially be addressed through early intervention in infant nutrition

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Normal lobular architecture usually present but may be distorted