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Although the term ferroptosis is relatively new, the idea of iron-dependent LPO as a mechanism of cell death has been around for more than 60 years [19]

investigated infertile PCOS patients with obesity randomly assigned to metformin 1000 mg BID or to metformin 1000 mg BID combined with low-dose liraglutide 1.2 mg/day for 12 week, and demonstrated that weight, BMI, and WC decreased with both treatments, without significant difference between the two arms [59]

Hormonal factors also play a major role in where stubborn fat accumulates

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This means timing matters more than with longer-acting compounds

This creates a devastating feedback loop: mast cells release histamine, which causes systemic inflammation