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Epinephrine narrows vessels, reducing blood flow so lidocaine clears slowly and extends pain relief
Moreover, curcumin inhibits the production of inflammatory mediators by regulating inflammatory signaling pathways such as nuclear factor -B (NF-B), mitogen-activated protein kinase (MAPK), and activator protein 1 (AP-1) pathways (171)
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The transcription factor p53 is a vital regulator that translates the occurrence of genotoxic stress into alterations of gene expression (Tishler et al., 1993)
Krimpenfort P, Berns A (March 2017)
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