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Supernatants were collected and stored at 20 C for 2 h and subsequently centrifuged at 15,000 g for 10 min at 4 C

The chronic immune activation and mycotoxin burden of systemic Candida overgrowth places sustained demand on the hypothalamic-pituitary-adrenal (HPA) axis, progressively depleting cortisol reserve and producing the flat diurnal cortisol curve characteristic of adrenal fatigue

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