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NICE first recommended the drug in draft guidance 2022, after a clinical trial of just under 2000 volunteers found that people lost on average 12% more weight with semaglutide alongside supervised weight loss coaching (BMJ 2023;380:556)

EGFR indicates how well the kidneys are functioning by measuring how much blood passes through the glomeruli each minute

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Phase 2 retatrutide data suggest approximately 2428% body weight reduction at equivalent timepoints, though Phase 3 confirmation is pending

As shown in Scheme 23

Research also shows that people with prediabetes had some improvement in their blood sugar levels after taking ALC for two months