Tirzepatide is the active receptor in Mounjaro and Zepbound injections
Possible side effects, while rare, may include: Most patients notice reduced appetite and fewer cravings within the first week
Access for free at This work is a derivative of Clinical Procedures for Safer Patient Care by British Columbia Institute of Technology and is licensed under CC BY 4.0 This work is a derivative of Clinical Procedures for Safer Patient Care by British Columbia Institute of Technology and is licensed under CC BY 4.0 American Diabetes Association
Accessed March 31, 2026
For example, between January 2021 and May 2023, a European analysis of 31,444 reports for semaglutide, liraglutide, and tirzepatide combined found that tirzepatide accounted for only 740 reports (2.3%) , with just four cases of suicidal events linked to its use
For instance, the OASIS 1 trial found a mean weight loss of 14.9% for those on semaglutide tablets, compared to just 2.4% in the placebo group