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Fusions with the [G 4 S] 3 A linker to the antibody light chain displayed potent GLP-1R activation (EC 50 : 100300 pM) whilst PCSK9 binding activity decreased by 2-70-fold relative to the parental anti-PCSK9 antibodies

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NCT01619345) was conducted in 26 healthy men in a fasting state who received a single dose of 10 mg orally administered semaglutide containing a labelled ion exchange resin

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