Underlying cause (non-hormonal causes may respond differently than androgenetic alopecia)
Choy L, Derynck R
A trace that ignores the complex is measuring the wrong molecule
(4) Macro-B12 becomes a reasonable consideration when a value is very high, persists over time, comes with no B12 exposure, sits alongside an unrevealing workup, or disagrees with functional markers
The "rapid reversal" group (approximately 10-15% of users) experiences concerning quick benefit loss within weeks of discontinuation, typically involving users who applied very high concentrations creating dependency-like patterns, possessed severe underlying skin conditions requiring ongoing treatment, experienced significant lifestyle or environmental stressors overwhelming skin resilience, discontinued abruptly without tapering from high-dose protocols, or had unrealistic perception inflation during treatment leading to exaggerated reversal perception
These side effects were usually mild or moderate, often improved with time, and only a small number of participants stopped treatment because of them