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Duration is usually time-limited, with frequent reassessment of benefits, side effects, and quality of life

Key takeaways Nausea is the most common side effect of semaglutide, affecting between 20% to 50% of people taking Ozempic, Wegovy, or Rybelsus

Semaglutide produced greater weight loss than placebo across the STEP trial program, but we will not quote a specific average here because individual results vary widely

continuing through this phase typically leads to full symptom fade

In the liver, it can increase insulin sensitivity, inhibit hepatic gluconeogenesis, and affect ectopic lipid accumulation

[6] Large observational studies and meta-analyses examining GLP-1 receptor agonists, including semaglutide, suggest that the absolute risk increase attributable to the medication is small, with no clear increased risk versus comparator treatments