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10.1080/19490976.2021.1875774 Gut Microbes

Nat Commun 10 , 924 (2019)

Whilst GLP-1 receptor activation can exert multiple direct neuroprotective effects, the protective influence of GLP-1 receptor agonists may occur indirectly through the restoration of the dysfunctional insulin signaling associated with neurodegenerative disease

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Proinflammatory cytokines produced by microglia and astrocytes upon activation cause upregulation of MMP-9 expression in endothelial cells, which results in the degradation of tight junction proteins and causes the breakdown of the BBB (223)

in 2023, they showed that SLC25A39 is not only a transporter but a dynamic sensor that regulates the amount of glutathione in the mitochondria and adjusts those levels accordingly