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Summary: Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) showing promising early evidence for significant weight reduction, improved metabolic markers, and reduced liver fat, but it has not yet received MHRA or EMA approval

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Mutations Q234 3.37b A, V237 3.40b L and V237 3.40b F decreased the potency (EC 50 ) of GLP-1(7-36) by 15-fold, 6-fold and 257-fold, respectively ( Fig