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Flavonoids have limitations with their structure, nature, absorption, molecular weight, toxic flavonoid-drug interactions and high first pass metabolism leading to their reduced bioavailability, therefore, by incorporating them into an effective nanocarrier system these challenges can be overcome (Caro-Ordieres et al
A recent study found that NRF1 can also regulate GPX4 [12]
10.1016/j.jaip.2018.01.031 14 BousquetJ.Van CauwenbergeP.At KhaledN.BachertC.Baena-CagnaniC
Acknowledgements This work was supported by the NIA (R00AG037574 and R56AG052981), the Prevent Cancer Foundation, the American Institute for Cancer Research (AICR), the American Federation for Aging Research (AFAR) and Einstein Startup Funds to D.M.H
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