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GLP-1RAs have demonstrated potential in treating liver diseases, cirrhosis, respiratory diseases, and neurodegenerative conditions, such as Alzheimers and Parkinsons, in addition to their glucose-lowering effects (Meh et al., 2023
These individuals may be at higher risk for complications from medication-induced constipation and may require specialized management strategies
A recent meta-analysis of randomized controlled trials (RCTs), including AMPLITUDE-O, examining six GLP-1 receptor agonists (lixisenatide, liraglutide, subcutaneous semaglutide, exenatide, dulaglutide, and efpeglenatide) reported a 21% reduction in a composite kidney outcome (macroalbuminuria, doubling of serum creatinine or 40% eGFR decline, RRT, or death from kidney disease), corresponding to a number needed to treat of 47 [73]
