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Semaglutide carries important safety warnings, including a boxed warning for medullary thyroid carcinoma (MTC) risk and contraindications for patients with personal/family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

These results, while striking, come from a single small trial and require confirmation in larger studies before any treatment conclusions can be drawn

Meanwhile, a post-hoc analysis of the STEP 1 and STEP 4 trials showed that semaglutide 2.4 mg was associated with an approximately 60% reduction of the 10-years risk of T2D according to the Cardiometabolic Disease Staging (CMDS) calculator, regardless of patients baseline glycemic status 74

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