GLP-1 receptor agonists have become a cornerstone of type 2 diabetes management because of their ability to improve glycemic control while promoting weight loss and reducing cardiovascular risk in appropriate patient populations. Foundayo is a once-daily, non-peptide oral GLP-1 receptor agonist that can be taken without food or water restrictions. The convenience of oral administration could expand access to GLP-1 therapy and potentially encourage earlier use in primary care settings. The ACHIEVE-3 findings are particularly notable because they provide the first direct phase 3 comparison between two oral GLP-1 therapies
LTD, New Delhi, pp 443478 Sommella E, Pepe G, Ventre G, Pagano F, Conte GM, Ostacolo C, Manfra M, Tenore GC, Russo M, Novellino E, Campiglia P (2016) Detailed peptide profiling of Scotta: from a dairy waste to a source of potential health-promoting compounds
Similar results were derived from the analysis of Italian administrative health databases of the Lombardy region, demonstrating a greater risk of hospitalization for renal disease compared to SGLT-2i (HR 2.23, CI 95% 1.483.43) [38]
Still, there was no significant variation between the treatments in regulation of O 2 content suggesting similar mode of regulation of the treatments
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Provenzano PP, Alejandro-Osorio AL, Valhmu WB, et al