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Table 2 summarizes RCTs of dual and triple GLP1-RA use in T2DM

How does TAD-600 work

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Of greater clinical significance are potential safety concerns that require further investigation in larger trials: Heart rate elevation glucagon is known to have chronotropic effects, and increases in resting heart rate were observed in some trial participants

Therefore, the aforementioned novel applications of GLP-1RAs all have the potential to bolster treatment and management options for the field as a whole, and new research continues to illuminate the physiological mechanisms behind this observed neuroprotective effect

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