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The FDA-labeled maintenance doses for weight reduction are 5 mg, 10 mg, or 15 mg weekly, chosen based on response and tolerability

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Another study in colonic-sensitized rat models demonstrated that exendin-4 treatment dose-dependently reduced visceral hypersensitivity by upregulating serotonin transporter (SERT) expression and downregulating tryptophan hydroxylase-1 (TPH-1) expression [57]